Chronic Obstructive Pulmonary Disease (COPD)

Critical role of RIG-I-like receptors in inflammation in chronic obstructive pulmonary disease.

Zhang Q1, Wan H, Huang S, Zhang Y, Wang Y, Guo X, He P, Zhou M.
Author information

Abstract
INTRODUCTION:
Viral infection is a significant cause of chronic obstructive pulmonary disease (COPD) and acute exacerbation of COPD. Retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation associated gene 5 (MDA-5), are important pattern recognition receptors for viral elimination.
OBJECTIVE:
The study aims to investigate the role of RIG-I and MDA-5 in COPD pathogenesis.
METHODS:
We examined the expression of RIG-I and MDA-5 by immunohistochemistry, real-time PCR and Western blots in COPD patients and control subjects.
RESULTS:
Our results showed that MDA-5 expression was upregulated in lung tissues and peripheral blood mononuclear cells of COPD patients and there was a negative correlation between MDA-5 mRNA levels and forced expiratory volume in 1 s %pred. COPD patients had higher interleukin (IL)-1 and IL-8 mRNA expression levels, and these inflammatory cytokines positively correlate with MDA-5 levels. However, there was no difference in the expression of RIG-I between COPD patients and control subjects.
CONCLUSION:
Our results suggested that MDA-5, but not RIG-I, may play a critical role in airway inflammation in COPD.
© 2014 John Wiley & Sons Ltd.

:: Courtesy NCBI (National Center for Biotechnology Information) Database and The NIH (National Institutes of Health) ::

http://www.ncbi.nlm.nih.gov/pubmed/24992168
http://www.ncbi.nlm.nih.gov/pubmed/24988605
http://www.ncbi.nlm.nih.gov/pubmed/24978309


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