Cancer

The role of melanogenesis in regulation of melanoma behavior: Melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways.

Slominski A1, Kim TK2, Brożyna AA3, Janjetovic Z2, Brooks DL2, Schwab LP2, Skobowiat C2, Jóźwicki W3, Seagroves TN2.

Abstract
To study the effect of melanogenesis on HIF-1α expression and attendant pathways, we used stable human and hamster melanoma cell lines in which the amelanotic vs. melanotic phenotypes are dependent upon the concentration of melanogenesis precursors in the culture media. The induction of melanin pigmentation led to significant up-regulation of HIF-1α, but not HIF-2α, protein in melanized cells for both lines. Similar upregulation of nuclear HIF-1α was observed in excisions of advanced melanotic vs. amelanotic melanomas. In cultured cells, melanogenesis also significantly stimulated expression of classical HIF-1-dependent target genes involved in angiogenesis and cellular metabolism, including glucose metabolism and stimulation of activity of key enzymes in the glycolytic pathway. Several other stress related genes containing putative HRE consensus sites were also upregulated by melanogenesis, concurrently with modulation of expression of HIF-1-independent genes encoding for steroidogenic enzymes, cytokines and growth factors. Immunohistochemical studies using a large panel of pigmented lesions revealed that higher levels of HIF-1α and GLUT-1 were detected in advanced melanomas in comparison to melanocytic nevi or thin melanomas localized to the skin. However, the effects on overall or disease free survival in melanoma patients were modest or absent for GLUT-1 or for HIF-1α, respectively. In conclusion, induction of the melanogenic pathway leads to robust upregulation of HIF-1-dependent and independent pathways in cultured melanoma cells, suggesting a key role for melanogenesis in regulation of cellular metabolism.
Copyright © 2014 Elsevier Inc. All rights reserved.

:: Courtesy NCBI (National Center for Biotechnology Information) Database and The NIH (National Institutes of Health) ::

http://www.ncbi.nlm.nih.gov/pubmed/24999312 
http://www.ncbi.nlm.nih.gov/pubmed/24999308 
http://www.ncbi.nlm.nih.gov/pubmed/24999009 
http://www.ncbi.nlm.nih.gov/pubmed/24997364 
http://www.ncbi.nlm.nih.gov/pubmed/24995613 
http://www.ncbi.nlm.nih.gov/pubmed/24991577


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5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
ACOT13 Human

Acyl-CoA Thioesterase 13 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
DIRAS1 Human

DIRAS family, GTP-binding RAS-like 1 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
LSM1 Human

LSM1 Homolog, U6 Small Nuclear RNA Associated Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
MAGEA3 Human

Melanoma Antigen Family A, 3 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
SIRT3 Human

Sirtuin 3 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
PNPO Human

Pyridoxamine 5'-Phosphate Oxidase Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
CDKN3 Human

Cyclin-Dependent Kinase Inhibitor 3 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 3600)
Qty
CBR1 Antibody

Carbonyl Reductase-1, Monoclonal Mouse Anti Human Antibody

5µg - ($ 50)
20µg - ($ 130)
100µg - ($ 450)
Qty
NMI Human

N-Myc Interactor Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
MAPRE1 Human

Microtubule-Associated Protein, RP/EB Family, Member 1 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
APEX1 Human

APEX Nuclease-1 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
TXNRD1 Human 161-649 a.a.

Thioredoxin Reductase 1 161-649 a.a. Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
TNF a Rabbit

Tumor Necrosis Factor-Alpha Rabbit Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
IL 1RA Horse

Interleukin-1 Receptor Antagonist Horse Recombinant

20µg - ($ 50)
100µg - ($ 130)
1mg - ($ 990)
Qty
CSTA Human

Cystatin-A Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
DHFR Mouse

Dihydrofolate Reductase Mouse Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
BCAS2 Human

Breast Carcinoma Amplified Sequence 2 Human Recombinant

1µg - ($ 50)
5µg - ($ 130)
50µg - ($ 1200)
Qty
S100A2 Human

S100 Calcium Binding Protein A2 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
NUCB2 Human, His

Nucleobindin-2 Human Recombinant, His Tag

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
CDC37 Human, His

Cell Division Cycle 37 Human Recombinant, His Tag

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
CLIC4 Human

Chloride Intracellular Channel 4 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 3600)
Qty
IGFBP 4 Human

Insulin-Like Growth Factor Binding Protein-4 Human

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 3900)
Qty
S100A7 Human

S100 Calcium Binding Protein A7 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
PI16 Human

Peptidase Inhibitor 16 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
ALKBH3 Human

ALKB Alkylation Repair Homolog 3 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
CMPK1 Human

Cytidine Monophosphate Kinase 1 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 3600)
Qty
CSTA Human, His

Cystatin A Human Recombinant, His tag

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
VOPP1 Human

Vesicular Overexpressed in Cancer, Prosurvival Protein 1 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
SERPINB5 Human

Serpin Peptidase Inhibitor, Clade B Member 5 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
MET Human

Met Proto-Oncogene Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
100µg - ($ 1000)
Qty
MET Human, GST

Met Proto-Oncogene Human Recombinant, GST Tag

2µg - ($ 175)
5µg - ($ 270)
10µg - ($ 490)
Qty
NUCB2 Human

Nucleobindin-2 Human Recombinant

20µg - ($ 50)
100µg - ($ 130)
1mg - ($ 990)
Qty
PTGES2 Human

Prostaglandin E Synthase 2 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
AGR3 Human

Anterior Gradient Protein 3 Homolog Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
FASLG Human, HEK

FAS Ligand Human Recombinant, HEK

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 3800)
Qty
NAT1 Human

N-Acetyltransferase 6 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 5200)
Qty
DCK Human

Deoxycytidine Kinase Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 3600)
Qty
DRG1 Human

Developmentally Regulated GTP Binding Protein 1 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
SULT1A2 Human

Sulfotransferase Family, Cytosolic, 1A, Member 2 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
SERPINA1 Human, Active

Recombinant Human Alpha-1 Antitrypsin, Active

20µg - ($ 50)
100µg - ($ 130)
1mg - ($ 1050)
Qty
DCUN1D2 Human

DCN1 Defective in Cullin Neddylation 1 Domain Containing 2 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
MAPRE2 Human

Microtubule-Associated Protein, RP/EB Family, Member 2 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
DENR Human

Density-Regulated Protein Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
MDC Rat

Macrophage-Derived Chemokine (CCL22) Rat Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
FAM3C Human

Family with Sequence Similarity 3, Member C Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
ODC1 Human

Ornithine Decarboxylase 1 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
CST9 Human

Cystatin 9 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
TNF a Human, HEK

Tumor Necrosis Factor-alpha Human Recombinant, HEK

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
VEGF (121a.a.) Human, HEK

Vascular Endothelial Growth Factor (121) Human Recombinant, HEK

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
pro-IGF2 Human

Pro-Insulin Like Growth Factor-2 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 4800)
Qty
DNAJB8 Human

DnaJ (Hsp40) Homolog, Subfamily B, Member 8 Human Recombinant

5µg - ($ 50)
25µg - ($ 130)
1mg - ($ 2700)
Qty
GPX1 Human

Glutathione Peroxidase 1 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
CST1 Human

Cystatin SN Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
TPM3 Human

Tropomyosin-3 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
TSSC4 Human

Tumor Suppressing Subtransferable Candidate 4, Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 3600)
Qty
GNB2L1 Human

Guanine Nucleotide Binding Protein beta polypeptide 2-like 1 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
DCTPP1 Human

dCTP Pyrophosphatase 1 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
PSMB2 Human

Proteasome Subunit Beta Type 2 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
GIPC2 Human

GIPC PDZ Domain Member 2 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
TNF a Canine

Tumor Necrosis Factor-Alpha Canine Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
MAGEA5 Human

Melanoma Antigen Family A, 5 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
ATG4B Human

ATG4 Autophagy Related 4 Homolog B Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 3600)
Qty
SPIN1 Human

Spindlin-1 Human Recombinant

1µg - ($ 50)
5µg - ($ 130)
50µg - ($ 1200)
Qty
IL 1RA Rat

Interleukin-1 Receptor Antagonist Rat Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
PBK Human

PDZ Binding Kinase Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 3600)
Qty
IL 1RA Mouse, His

Interleukin-1 Receptor Antagonist Mouse Recombinant, His Tag

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
PNPO Antibody

Pyridoxamine 5'-Phosphate Oxidase, Mouse Anti Human

5µg - ($ 50)
20µg - ($ 130)
100µg - ($ 450)
Qty
OVCA2 Human

Ovarian Tumor Suppressor Candidate 2 Human Recombinant

1µg - ($ 50)
5µg - ($ 130)
50µg - ($ 1200)
Qty
HSPB9 Human

Heat Shock Protein B9 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
CYR61 Human

Cysteine-Rich Angiogenic Inducer 61 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 3510)
Qty
ADRM1 Human

Adhesion Regulating Molecule 1 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
ORAOV1 Human

Oral Cancer Overexpressed 1 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
MAGEA6 Human

Melanoma Antigen Family A, 6 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
100µg - ($ 1200)
Qty
CKMT1A Human

Creatine Kinase, Mitochondrial 1A Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
DNAJC12 Human

DnaJ (Hsp40) Homolog, Subfamily C, Member 12 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
HBXIP Human

Hepatitis B Virus x Interacting Protein Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
OLA1 Human

Obg-Like ATPase 1 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 3600)
Qty
TCEAL7 Human

Transcription Elongation Factor A (SII)-Like 7 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
KLK5 Human

Kallikrein-5 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
100µg - ($ 1200)
Qty
EMCN Human

Endomucin Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
100µg - ($ 1200)
Qty
LDOC1L Human

Leucine Zipper, Down-Regulated in Cancer 1-Like Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
HOPX Human

HOP homeobox Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
DKK3 Human

Dickkopf-Related Protein 3 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
ATPIF1 Human

ATPase Inhibitory Factor 1 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
Midkine Mouse

Midkine Mouse Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
DKK2 Human

Dickkopf-Related Protein 2 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
100µg - ($ 1200)
Qty
GKN1 Human

Gastrokine 1 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
100µg - ($ 1200)
Qty
Midkine Human

Midkine Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
GIPC2 Antibody

GIPC PDZ Domain Member 2, Mouse Anti Human

5µg - ($ 50)
20µg - ($ 130)
100µg - ($ 450)
Qty
KRT23 Antibody

Cytokeratin 23, Mouse Anti Human

5µg - ($ 50)
20µg - ($ 130)
100µg - ($ 450)
Qty
FASLG Human

FAS Ligand Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
XPA Human

Xeroderma Pigmentosum, Complementation Group A Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
Bcl XL Mouse

B-Cell Leukemia/Lymphoma XL Mouse Recombinant

10µg - ($ 50)
50µg - ($ 130)
1mg - ($ 1800)
Qty
NRG1 B1 Human

Neuregulin-1/Heregulin-b1 Human Recombinant

10µg - ($ 50)
50µg - ($ 130)
1mg - ($ 1350)
Qty
TNF a Rhesus Macaque

Tumor Necrosis Factor-Alpha Rhesus Macaque Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
LIN28B Human

LIN28B Human Recombinant

1µg - ($ 50)
5µg - ($ 130)
50µg - ($ 1200)
Qty
RASSF1A Human

Ras association domain-containing protein 1 Human Recombinant

5µg - ($ 50)
25µg - ($ 130)
1mg - ($ 2700)
Qty
KLK1 Human, His

Kallikrein-1 Human Recombinant, His Tag

2µg - ($ 50)
10µg - ($ 130)
100µg - ($ 1200)
Qty
Midkine Rat

Midkine Rat Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
GLTP Human

Glycolipid Transfer Protein Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
FXYD5 Human

FXYD5 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
NCEH1 Human

Neutral Cholesterol Ester Hydrolase 1 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
Pleiotrophin Human

Pleiotrophin Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
WLS Human

Wntless Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
RASSF3 Human

Ras Association Domain-Containing Protein 3 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
MAEA Human

Macrophage Erythroblast Attacher Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
CD74 Human

CD74 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
SMCP Human

Sperm Mitochondria-Associated Cysteine-Rich Protein Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
PSPN Mouse

Persephin Mouse Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
PSPN Human

Persephin Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
NOV Human

Nephroblastoma Overexpressed Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 3510)
Qty
SPA17 Human

Sperm Autoantigenic Protein 17 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
TMEFF1 Human

TMEFF1 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
ZA2G Human

Zinc-alpha 2 glycoprotein Human

1µg - ($ 50)
5µg - ($ 130)
50µg - ($ 1100)
Qty
APOD Human, HEK

Apolipoprotein-D Human Recombinant, HEK

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
KLK3 Human

Kallikrein-3 Human

2µg - ($ 50)
10µg - ($ 130)
100µg - ($ 1100)
Qty
THRSP Human

Thyroid Hormone Responsive Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
STC 2 Human, His

Stanniocalcin-2 Human Recombinant, His Tag

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
RARRES1 Human

Retinoic Acid Receptor Responder 1 Human Recombinant

5µg - ($ 50)
25µg - ($ 130)
1mg - ($ 2700)
Qty
SPINK7 Human

Serine Peptidase Inhibitor Kazal Type 7 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
GKN2 Human

Gastrokine 2 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
FIBP Human

FGF-1 Intracellular-Binding Protein Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
FeLV

Feline Leukemia Virus p27 Recombinant

100µg - ($ 150)
500µg - ($ 600)
1000µg - ($ 1200)
Qty
GPNMB Human

Glycoprotein Nmb Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
GPNMB Human, HEK

Glycoprotein Nmb Human Recombinant, HEK

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
SCGB1D1 Human

Secretoglobin Family 1D, Member 1 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
KLK2 Human

Kallikrein-2 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
HES2 Human

Hairy and Enhancer of Split 2 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
CTSF Human

Cathepsin-F Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
FAM84A Human

Family with Sequence Similarity 84, Member A Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
LIMD2 Human

LIM Domain Containing 2 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
GIMAP6 Human

GTPase, IMAP Family Member 6 Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 3600)
Qty
PPP1R11 Human

Protein Phosphatase 1, Regulatory Subunit 11 Human Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
LGALS1 Mouse

Galectin-1 Mouse Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
Pleiotrophin Human, HEK

Pleiotrophin Human Recombinant, HEK

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
LGALS4 Mouse

Galectin-4 Mouse Recombinant

2µg - ($ 50)
10µg - ($ 130)
1mg - ($ 5200)
Qty
XAGE1A Human

X Antigen Family, Member 1A Human Recombinant

1µg - ($ 50)
5µg - ($ 130)
50µg - ($ 1200)
Qty
TP53I3 Antibody

Tumor Protein p53 Inducible Protein 3, Mouse Anti Human

5µg - ($ 50)
20µg - ($ 130)
100µg - ($ 450)
Qty
KLK3 Antibody

Kallikrein-3, Mouse Anti Human

5µg - ($ 50)
20µg - ($ 130)
100µg - ($ 450)
Qty

Note:

BioInfoMedical is a leading global provider of products and services used in gene, protein and cell research, drug discovery and development, biopharmaceutical manufacturing and transfer of new technologies.

BioInfoMedical specializes in satisfying customers demand for high quality cytokine products including E. coli, insect, and mammalian cell-derived recombinant proteins, monoclonal/polyclonal antibodies, and other cytokine-related reagents.

The specific products and services, offered by BioInfoMedical Biotechnology, range from cytokines and related molecules (such as interleukins, growth factors, chemokines), adhesion molecules, neurotrophic factors, proteases, receptors, developmental proteins, apoptosis and signal transduction-related molecules, and full Technology-License packages with a comprehensive course at ours/customers lab facility. Diagnostic tests are also available in broad spectrum of diseases - Staph, Strep, Malaria, Typhoid, Sexually Transmitted Diseases, Cholera, autoimmune diseases, and diseases like Cancer described on this page..

Please contact us with any questions or inquiries regarding our above stated goals. We will continue to update and improve on this website to meet the needs of You, our customers and to futher the larger, global need for disease research and ultimate cures.