Autism

Neonatal cytokines and chemokines and risk of Autism Spectrum Disorder: the Early Markers for Autism (EMA) study: a case-control study.

Zerbo O1, Yoshida C, Grether JK, Van de Water J, Ashwood P, Delorenze GN, Hansen RL, Kharrazi M, Croen LA.
Author information

Abstract
BACKGROUND:
Biologic markers of infection and inflammation have been associated with Autism Spectrum Disorders (ASD) but prior studies have largely relied on specimens taken after clinical diagnosis. Research on potential biologic markers early in neurodevelopment is required to evaluate possible causal pathways and screening profiles.
OBJECTIVE:
To investigate levels of cytokines and chemokines in newborn blood specimens as possible early biologic markers for autism.
METHODS:
We conducted a population-based case-control study nested within the cohort of infants born from July 2000 to September 2001 to women who participated in the prenatal screening program in Orange County, California, USA. The study population included children ascertained from the California Department of Developmental Services with Autism Spectrum Disorder (ASD, n = 84), or developmental delay but not ASD (DD, n = 49), and general population controls randomly sampled from the birth certificate files and frequency matched to ASD cases on sex, birth month and birth year (GP, n = 159). Cytokine and chemokine concentrations were measured in archived neonatal blood specimens collected for routine newborn screening.
RESULTS:
Cytokines were not detected in the vast majority of newborn samples regardless of case or control status. However, the chemokine monocyte chemotactic protein-1 (MCP-1) was elevated and the chemokine Regulated upon Activation Normal T-Cell Expressed and Secreted (RANTES) was decreased in ASD cases compared to GP controls. The chemokines macrophage inflammatory protein-1alpha (MIP-1α) and RANTES were decreased in children with DD compared to GP controls.
CONCLUSION:
Measurement of immune system function in the first few days of life may aid in the early identification of abnormal neurodevelopment and shed light on the biologic mechanisms underlying normal neurodevelopment.
PMID: 24951035 [PubMed - in process] PMCID: PMC4080514 Free PMC Article

:: Courtesy NCBI (National Center for Biotechnology Information) Database and The NIH (National Institutes of Health) ::

http://www.ncbi.nlm.nih.gov/pubmed/24951035
http://www.ncbi.nlm.nih.gov/pubmed/24934179
http://www.ncbi.nlm.nih.gov/pubmed/24797632
http://www.ncbi.nlm.nih.gov/pubmed/24061853
http://www.ncbi.nlm.nih.gov/pubmed/23994594
http://www.ncbi.nlm.nih.gov/pubmed/23925007

 


The following product(s) are being used for the research of the above disease, illness or condition
Eotaxin Human

Eotaxin Human Recombinant (CCL11)

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
Secretin Human

Secretin Human

1mg - ($ 50)
5mg - ($ 130)
25mg - ($ 390)
Qty
Eotaxin 1 Antibody

Eotaxin-1, Mouse Anti-Human

500µg - ($ 155)
1mg - ($ 290)
Qty
Eotaxin 2 Human

Eotaxin-2 Human Recombinant (CCL24)

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
GLO1 Human

Glyoxalase-I Human Recombinant

10µg - ($ 50)
50µg - ($ 130)
1mg - ($ 1800)
Qty
Eotaxin 2 Mouse

Eotaxin-2 Mouse Recombinant (CCL24)

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty
ADSL Human

Adenylosuccinate Lyase Human Recombinant

5µg - ($ 50)
20µg - ($ 130)
1mg - ($ 2700)
Qty

Note:

BioInfoMedical is a leading global provider of products and services used in gene, protein and cell research, drug discovery and development, biopharmaceutical manufacturing and transfer of new technologies.

BioInfoMedical specializes in satisfying customers demand for high quality cytokine products including E. coli, insect, and mammalian cell-derived recombinant proteins, monoclonal/polyclonal antibodies, and other cytokine-related reagents.

The specific products and services, offered by BioInfoMedical Biotechnology, range from cytokines and related molecules (such as interleukins, growth factors, chemokines), adhesion molecules, neurotrophic factors, proteases, receptors, developmental proteins, apoptosis and signal transduction-related molecules, and full Technology-License packages with a comprehensive course at ours/customers lab facility. Diagnostic tests are also available in broad spectrum of diseases - Staph, Strep, Malaria, Typhoid, Sexually Transmitted Diseases, Cholera, autoimmune diseases, and diseases like Autism described on this page..

Please contact us with any questions or inquiries regarding our above stated goals. We will continue to update and improve on this website to meet the needs of You, our customers and to further the larger, global need for disease research and ultimate cures.